A product of

Atheris

distributed by

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Atheris Laboratories

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Founded in 1995 by Dr Reto Stöcklin, Atheris Laboratories is a family owned and family driven biotechnology company. Atheris has built a unique, world-class expertise and technology platform pertaining to the identification and characterisation of biomolecules. To assist its drug discovery programs, Atheris has developed proprietary databases on animal venoms and antibiotics. Using state-of-the-art separation and analytical methods, Atheris is also a world leader in performing mass spectrometry (MS) assays on polypeptides for in vivo metabolic studies.
 
 
For more information, please visit the Atheris website.
 

Selected references (ask for reprints)

  • Gerwig, G.J., Hocking, H.G., Stöcklin, R., Kamerling, J.P. and Boelens, R. (2013). Glycosylation of conotoxins. Mar Drugs. 11(3):623-42.
  • Koua, D., Laht, S., Kaplinski, L., Stöcklin, R., Remm, M., Favreau, P. and Lisacek, F. (2013). Position-specific scoring matrix and hidden Markov model complement each other for the prediction of conopeptide superfamilies. Biochim Biophys Acta. doi:pii: S1570-9639(12):00295-6.
  • Brauer, A., Kurz, A., Stockwell, T., Heidler, J., Wittig, I., Kauferstein, S., Mebs, D., Stöcklin, R. and Remm, M. (2012). The mitochondrial genome of the venomous cone snail Conus consors. PlosONE. 7(12)e51528:1-10.
  • Hocking, H.G., Gerwig, G.J., Dutertre, S., Favreau, P., Stöcklin, R., Kamerling, J.P. and Boelens, R. (2012). Structure of the O-glycosylated conopeptide CcTx from Conus consors venom. Chemistry. 19(3):870-879.
  • Leonardi, A., Biass, D., Kordiš, D., Stöcklin, R., Favreau, P. and Križaj, I. (2012). Conus consors snail venom proteomics proposes functions, pathways and novel families involved in its venomic system. J. Proteome Res. 11(10):5046-5058.
  • Oldrati, V., Bianchi, E. and Stöcklin, R. (2012). Spider venom components as drug candidates. In: Spider Ecophysiology (Nentwig, W. Ed.). Springer Verlag, Heidelberg, Germany. In press.

  • Violette, A., Biass, D., Dutertre, S., Koua, D., Piquemal, D., Pierrat, F., Stöcklin, R. and Favreau, P. (2012). Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J. Proteomics. 75(17):5215-25.

  • Puillandre, N., Koua, D., Favreau, P., Olivera, B.M. and Stöcklin, R. (2012). Molecular phylogeny, classification and evolution of conopeptides. J. Mol. Evol. 74(5-6):297-309.

  • Koua, D., Brauer, A., Laht, S, Kaplinski, L., Favreau, P., Remm, M., Lisacek, F. and Stöcklin, R. (2012). ConoDictor: a tool for prediction of conopeptide superfamilies. Nucleic Acids Res. 40(Web Server issue):W238-41.

  • Favreau, P., Benoit, E., Hocking, E., Carlier, L., D’hoedt, D., Leipold, E., Markgraf, D., Schlumberger, S., Cordova, M., Gaertner, H., Paolini-Bertrand, M., Hartley, O., Tytgat, J., Heinemann, S., Bertrand, D., Boelens, R., Stöcklin, R. and Molgo, J. (2012). A novel mu-conopeptide, CnIIIC, exerts potent and preferential inhibition of Nav1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Brit. J. Pharmacol.166(5):1654-68.

  • Harvey, A.L. and Stöcklin, R. (2012). From venoms to drugs: introduction. Editorial. Toxicon, 59(4):433-433.

  • Stöcklin, R. and Vorherr, T. (2011). Future perspectives of venoms for drug discovery. Pharmanufacturing: The international peptide review. (Nov. 2011):21-24.

  • Favreau, P. and Stöcklin, R. (2009). Marine snail venoms: use and trends in receptor and channel neuropharmacology. Current Opinion in Pharmacology (COPHAR), 9(5):594-601.
  • Biass, D., Dutertre, S., Gerbault, A., Menou, J.-L., Offord, R.E., Favreau, P. and Stöcklin, R. (2009). Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J. Proteomics, 72(2)210-218.
  • Stöcklin, R., Favreau, P., Thai, R., Pflugfelder, J., Bulet, P. and Mebs, D. (2009). Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae), Toxicon 55(1):20-7.
  • Menin, L., Perchuc, A., Favreau, P., Perret, F., Michalet, S., Schöni, R., Wilmer, M. and Stöcklin R. (2008). High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry. Toxicon 51(7):1288-1302.
  • Favreau, P., Cheneval, O., Menin, L., Michalet, S., Gaertner, H., Principaud, F., Thai, R., Ménez, A., Bulet, P. and Stöcklin, R. (2007). The venom of the snake genus Atheris contains a new class of peptides with clusters of histidine and glycine residues. Rapid Commun. Mass Spectrom. 21:406-412.
  • Favreau, P., Menin, L., Michalet, S., Perret, F., Cheneval, O., Stöcklin, M., Bulet, P. and Stöcklin, R. (2006). Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen. Toxicon 47(6):676-87.
  • Ménez, A., Stöcklin, R. and Mebs, D., 2006. ‘Venomics’ or: The venomous systems genome project. Toxicon, p. 255–259.
  • Stöcklin, R. and Favreau, P., 2002. Proteomics of venom peptides. In : Perspectives in molecular toxinology (Ménez A Ed.), John Wiley & Sons Ltd, Chichester, UK, p. 107-123.
More references
 

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