Natural Peptides to Drugs
- a proven efficiency with high success rate -
Melusine collections: unexplored compound libraries
We offer a broad choice of venom types and insect hemolymphs that are pre-fractionated in microplates, as well as a collection of synthetic peptides. The separated peptides and proteins are ready for low- or high-throughput screening in drug, pharmacological and cosmeceutical lead discovery. The Melusine microplates can be customized for your specific needs, -e.g.specific venoms or protein/peptide molecular sizes. Please, to discuss the numerous possibilities we offer.
* The typical hit rate of Melusine collections is as high as 0.1 to 1%!
Hits follow-up & deconvolution: a unique proprietary platform
The Melusine team offers a significant advantage for each microplate. It can perform the characterization of the bioactive fractions, sub-fractionation or micro-sequencing, scale-up, peptide synthesis or purification and deliver larger quantities of venom or any fraction thereof. Flexibility is one of the major strength of the Melusine team, just ask us!
On a fee-for-service basis on in the frame of R&D agreements, we routinely conduct a three-ways strategy in parallel to speed-up the process and reduce the costs:
- Sub-fractionation and purification for bioactivity-guided discovery;
- Mass spectrometry investigations (MS & MS/MS) for structure-driven discovery;
- Data- and text-mining loops in our databases for biocomputing assisted discovery.
* Our typical deconvolution success rate is in the range of 50%!
Hits to Lead: improving on Nature & relying on Nature
Using its proprietary Atheris bioinformatic and proteomic tools coupled to its long term expertise in protein engineering, the Melusine Team is also willing to participate in the identification and characterisation of natural (through screening of related biological sources) and synthetic (through drug design) analogues of identified hits for lead optimisation. Here again we have a three-ways parallel medicinal chemistry strategy:
- Biocomuting loops to identify analogues and key structural patterns;
- Screening of related venoms to broaden the natural biodiversity;
- Targeted in silico design of analogues with improved pharmacology.
* We deliver dozens of analogue structures for improved lead optimization!
Melusine collaboration & partnership: We like to please
The Melusine team is seeking to partner with biopharmaceutical companies to discover tomorrow's drugs. Because of our long experience in the field and our proprietary venom database, the Melusine team is a premium partner to accelerate considerably the discovery of novel bioactive molecules. The Melusine team is dedicated to contribute to the creation of value and intellectual property for its partners.
* We like to please beyond expectations, and... we never give up!
Please to discuss the possibilities
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